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A Pioneering Institutefor the next generationof Innovators
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Work with world-renowned professors and innovators. Earn global distinction in university admissions.

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Two Sigma Lab is a research and innovation institute where ambitious students work one-on-one with internationally recognized innovators.


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Our faculty publish in leading journals, win international awards, and pioneer technologies that shape the future.

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Guided by us, you design original research and innovation projects that showcase your passion and open doors to leading universities worldwide.

Our students have

  • Designed AI tools to detect depression in children
  • Revealed critical health gaps in marginalized communities
  • Identified novel biomarkers that advance understanding of brain disease

What impact could you imagine?

Two Sigma Lab

OUR STUDENTS WERE ACCEPTED INTO

Harvard logoStanford logoYale logoOxford logoCambridge logoMIT logoPrinceton logoETH zurich logocolumbia logoucl logoKCL logoLSE logo
Harvard logoStanford logoYale logoOxford logoCambridge logoMIT logoPrinceton logoETH zurich logocolumbia logoucl logoKCL logoLSE logo
Harvard logoStanford logoYale logoOxford logoCambridge logoMIT logoPrinceton logoETH zurich logocolumbia logoucl logoKCL logoLSE logo
Harvard logoStanford logoYale logoOxford logoCambridge logoMIT logoPrinceton logoETH zurich logocolumbia logoucl logoKCL logoLSE logo
/ our mission /
We Boost Academic Outcomes By Providing Transformative Research and Innovation Opportunities

Two Sigma Lab is a research and innovation institute for ambitious students worldwide. Our mission is to provide professional-level research and innovation opportunities to young scholars, enabling extracurricular projects of genuine intellectual and social impact.


We believe the next generation of innovators must learn to harness AI responsibly. At Two Sigma Lab, every project is human-led and AI-empowered. We give students hands-on experience with AI tools while reinforcing ethical guidelines for their effective use.


Every project combines four elements to create an ikigai for student impact:
  • Each student's unique strengths and passions
  • The mentorship by internationally renowned faculty
  • The standards of excellence that leading universities value
  • The effective and ethical use of AI as a research accelerator

Through close guidance from faculty who publish in leading journals, win international awards, and pioneer breakthrough technologies, students create research and innovation portfolios that demonstrate rigor, creativity, and impact. These achievements earn recognition in global university admissions and prepare students for future leadership.
BECOME FUTURE-READY IN A POST-AI WORLD

Our programs are built on a forward-looking competency model that equips students with the interdisciplinary skills required by top universities and future employers.

Technical

Sigma

Human Centric

We Celebrate Our Students
Every project is designed to open doors

Two Sigma Lab students finish with achievements that admissions officers instantly recognize. Their projects signal ambition, depth, and creativity at a level usually seen only in university scholars and industry professionals.

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Acceptance Rate to Elite Universities

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Published in International Journals

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Acceptance Rate into Top Companies like FAANG

0.0x

Increase in Future-ready reasoning skills

What Our Students Say

1 / 3
Catherine Vu
Master Fellow

Having had little to no experience in coding and computational biology, I felt like a fish out of the water when I first started on this project with Two Sigma Lab. But with the step-by-step guidance from my supervisor and instant feedback provided by the Two Sigma AI tools, I was able to grasp the concepts and skills needed to tackle the project. Overall, this has been an incredibly valuable experience that allowed me to work with large scale real-world data. Having the rare opportunity to publish a scientific paper has also been a major highlight for me!

Catherine Vu

Nanyang Junior CollegeSingapore

Hazel Ngo
Two Sigma Fellow

Through my growing experiences in the biosciences, I have come to realize that wet lab expertise is just as essential as strong data analysis skills, especially when a single experiment can generate massive, complex datasets. At Two Sigma Lab, I was introduced to AI-driven tools that provided clear guidance in tackling coding challenges and creating effective data visualizations to improve skills that I initially had little confidence. It has been challenging yet rewarding, and equipped me with a versatile skill set that will be indispensable in my long-term career of advancing impactful scientific discoveries.

Hazel Ngo

Stanford UniversityUSA

Bao Ha
Master Fellow

I always loved chemistry at high school but was not aware how it can be applied to problems in fields that seem totally unrelated. The research experience with Two Sigma Lab really opened my eyes about how different fields intertwine, and how I can create innovation by identifying these intersections. My mentor empowered me to think critically, to believe in myself and my goals. Finally, I achieved my dream internship and career through the referral given by my mentor. It was life-changing for me.

Bao Ha

Berlin University of TechnologyGermany

Building THE NEXT generation / >
Building THE NEXT generation / >
Building THE NEXT generation / >
Building THE NEXT generation / >
Your Impact Journey
Explore
STEP 1
Explore
Our core faculty and platform tools guide you to explore your interests and pursue the questions that matter most to you.
Design
STEP 2
Design
You and your mentor design a project that reflects your talents and highlights the qualities universities value. This could be original research, an AI tool with community impact, or a breakthrough experiment.
Create
STEP 3
Create
You bring your project to life with direct faculty mentoring and AI research copilots that handle routine tasks, supported asynchronously by your mentor.
Publish
STEP 4
Publish
By the end of our rigorous program, you complete a manuscript or innovation portfolio for publication. We put our name alongside yours, ensuring your work meets professional standards of scientific quality and integrity. Every student publication, once published, is transparent, verifiable, and publicly accessible.
Earn Life-Long Referrals
STEP 5
Earn Life-Long Referrals
Completing our program earns you lifelong access to our faculty network. Professors and innovators who know your work provide trusted referrals for university admissions, scholarships, and career opportunities — opening doors long after your project is complete.

FOUNDER

Our World-Class
Core Faculty
Google logoMIT logoYale logostandford logoPrinceton logoHarvard logoCambridge logoJohns hopkin logoOxford logo
Google logoMIT logoYale logostandford logoPrinceton logoHarvard logoCambridge logoJohns hopkin logoOxford logo
Google logoMIT logoYale logostandford logoPrinceton logoHarvard logoCambridge logoJohns hopkin logoOxford logo
Google logoMIT logoYale logostandford logoPrinceton logoHarvard logoCambridge logoJohns hopkin logoOxford logo

Your mentors are world-class faculty — never students.


Our faculty blend a rare combination of academic excellence, passion for mentorship, and global innovation. Trained at Harvard, Cambridge, Oxford, MIT, and Yale, they have published in leading journals, pioneered technologies, and helped students obtain admission to the world’s top universities at the undergraduate and graduate levels.

Our faculty have:

Published groundbreaking research in leading international journals

Over 10 years of experience advancing science as active researchers.

Guided hundreds of students in research and innovation for college admissions.

Earned degrees from the world’s most prestigious universities.

Built intelligent technologies at Fortune 500 companies.

Worked across countries and cultures, bringing deep empathy for international students

Our Publications
In Preparation
Illuminating health disparities between ethnic groups of Southeast Asia.
Light: Science & Application
A microscope on a needle uncovers the brain's secrets.
July 26, 2018
eLife
How your brain makes sense of sound in a surprisingly messy way.
June 26, 2018
Science
Dr. Titus Hoang's Research Highlighted in Science Magazine
June 18, 2014
eLife
How a motor protein transports RNAs inside the cell.
March 8, 2018
eLife
A molecule controls the speed of cellular cargo movement.
April 1, 2017
PNAS
Mutations in cellular transport machinery cause neurological diseases.
January 1, 2017
The EMBO Journal
Solving a decade-long puzzle: How retroviruses move inside the cell.
January 1, 2014
Molecular and Cellular Neuroscience
A new biomarker for Multiple Sclerosis
April 24, 2013
Our FELLOWSHIPSEvery journey is personal. Every project is unique.
Other programs recycle templates and call them research. At Two Sigma Lab every student designs a project that reflects their passions, strengths, and future goals. Whether you pursue original research or build an AI tool that changes your community, your project carries the authority of true innovation guided by faculty who are world-class leaders.
Fellowship Pathways
capstone-fellow

Capstone Fellow

Description:Explore a single idea with a mentor and produce a manuscript or portfolio.
Duration:3 months
Program Fee:$3,800
master-fellow

Masters Fellow

Description:Deeper faculty engagement leading to a manuscript for international publication or a fully developed innovation project.
Duration:6 months
Program Fee:$6,700
twosigma-fellow

AI Impact Fellow

Description:Design AI-driven projects that address real-world challenges at scale.
Duration:6 months
Program Fee:$6,700
twosigma-fellow

Two Sigma Fellow

Description:Comprehensive mentorship to design, execute, and showcase projects of professional caliber that become the centerpiece of your college applications.
Duration:9 months
Program Fee:$11,700
Fellow Selection
CRITERIA

Two Sigma Lab accepts applications from high school students age 14+ and undergraduate students worldwide.

Admission is highly selective.

Each student is chosen with care and paired with a professor or award-winning innovator who can mentor at the highest level. This ensures that every project reaches a standard that distinguishes your application worldwide.

We look for students who:
  • Ask big questions and chase bold ideas
  • Show early potential in research, engineering, or innovation
  • Embrace new technology and unconventional ways of thinking
  • Aim to use knowledge to make a real impact
Application
STEP 1
Application
Committee Review
STEP 2
Committee Review
Interview Round
STEP 3
Interview Round
Decision
STEP 4
Decision
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
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Launch your journey in research and innovation with Two Sigma Lab.

Applications are reviewed on a rolling basis, with admission reserved for the most exceptional students.

APPLY NOW
Start Building your Future / >
Start Building your Future / >
Start Building your Future / >
Start Building your Future / >
Reach out to us

Need immediate support? Contact us via email

Frequently Asked Questions

Questions we think you might like answers to

Two Sigma Lab is a global research and innovation institute that enables exceptional high school (age 14+) and undergraduate students to conduct original projects under the close guidance of world-class faculty. Students produce publishable research and innovation portfolios that meet the professional standards of international journals and industry.

We believe that in order to become innovative, students must work real innovators. Our edge is the caliber of our faculty. They are internationally recognized scientists, engineers and inventors who are published in the world’s most prestigious journals — including Nature, Science, and PNAS — and have been covered by outlets like The New York Times. Several have collaborated directly with Nobel Laureates and created disruptive tech at Fortune 500 companies, a testament to the level of excellence and mentorship we bring to our students.

Our faculty are researchers and innovators trained at leading institutions such as Harvard, Cambridge, Oxford, MIT, and Yale. They bring decades of combined experience in scientific discovery, technology development, and mentorship, ensuring students are guided with the same rigor found at the world’s top universities.

Admission is highly selective. We review applications on a rolling basis and typically admit only a small percentage of applicants. Each student is paired with a faculty mentor whose expertise aligns with their goals, ensuring projects meet the highest standards of excellence.

No. Our programs are designed to support motivated students at all levels. Each fellow is equipped with the training, tools, and faculty guidance necessary to complete work of genuine academic and professional caliber.

Time commitment varies by fellowship pathway. Students typically meet weekly with faculty over a period of three to nine months, with additional independent research required between sessions.

Tuition varies depending on the fellowship pathway. Full details on fees and payment options are outlined in our Fellowships and Pricing section.

Students are always credited as primary authors on publications and retain ownership of their intellectual property. Faculty may serve as co-authors to validate rigor and standards, but all work is transparently attributed to the student.

Mentorship is delivered online through structured structured sessions with faculty, supported by asynchronous feedback and AI copilots for routine tasks. This model ensures students receive sustained, personalized guidance while developing independent research skills.

Fellows pursue projects that reflect their passions and goals, from original scientific research to the design of AI tools with measurable community impact. All projects are held to rigorous academic and professional standards.

All completed projects are published on scientific preprint servers such as arXiv or bioRxiv, ensuring your work is transparent, verifiable, and publicly accessible. Beyond this, our faculty work with motivated students to pursue publication in peer-reviewed international journals. However, final acceptance depends on the quality of the work, the student’s effort, and the standards of each journal. We cannot ethically guarantee journal publication, but we do guarantee that your project will meet professional standards and be accessible to the public.

Completing a fellowship with Two Sigma Lab signals ambition, intellectual rigor, and creativity at a level rarely seen in high school or undergraduate applicants. Alumni stand out in competitive college admissions and gain a credential that carries weight in academic and professional settings.

Faculty guide students through preparing manuscripts for peer-reviewed journals and, where appropriate, assist in exploring patent applications. All publications and outputs are transparent, verifiable, and publicly accessible, demonstrating authentic achievement.

Our students have secured admission to leading global universities, including Ivy League and Oxbridge institutions. Each project is designed to provide distinction in admissions, complementing strong academic records and test scores.

Every student is matched with a dedicated faculty mentor who provides both academic and personal guidance. In addition, our structured curriculum and AI copilots reduce busywork, allowing students to focus on their core ideas.

Yes. While the core of our program is one-on-one mentorship, students are invited to join our broader network of fellows and alumni for discussions, workshops, and collaborations.

Yes. In addition to publications or innovation portfolios, all students who successfully complete a fellowship receive a certificate from Two Sigma Lab, verifying their participation and the rigor of their work.

Applications are reviewed on a rolling basis. Prospective fellows may apply through our Application Page, where they outline their interests and goals. Selected applicants are invited to an interview before final admission decisions are made.

More question?
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APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
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APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
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APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
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APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
APPLICATION OPEN // WE ARE ENROLLING OUR FIRST 100 STUDENTS WORLD-WIDE // SIGN UP!
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